| 3B | 10-day-dl (The Pittsburgh Pirates placed INF Ke'Bryan Hayes on the 10-day injured list with back tightness.) | |
| P | 15-day-dl (The Pittsburgh Pirates placed SP Marco Gonzales on the 15-day injured list.) | |
| P | 15-day-dl (The Pittsburgh Pirates placed RP Ryan Borucki on the 15-Day Injury List with left triceps inflammation.) | |
| C | 60-day-dl (The Pittsburgh Pirates placed C Jason Delay on the 10-day injured list.) | |
| P | 60-day-dl (The Pittsburgh Pirates placed RHP Dauri Moreta on the 60-day injured list.) | |
| C | 60-day-dl (The Pittsburgh Pirates placed C Endy Rodríguez on the 60-day injured list with an elbow injury.) | |
| P | 60-day-dl (The Pittsburgh Pirates placed RHP Johan Oviedo on the 60-day injured list with an elbow injury.) | |